Big data, big picture: Metabolomics meets systems biology
نویسندگان
چکیده
منابع مشابه
Systems Biology: The Big Picture
Microarray studies are capable of providing data for temporal gene expression patterns of thousands of genes simultaneously, comprising rich but cryptic information about transcriptional control. However available methods are still not adequate in extraction of useful information about transcriptional regulation from these data. This study presents a dynamic model of gene expression which allow...
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Better understanding and controlling complex systems has become a grand challenge not only for computer science, but also for the natural and social sciences. Many of these systems have in common that they can be studied from a network perspective. Consequently methods from network science have proven instrumental in their analysis. In this article, I introduce the macroscopic perspective that ...
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Motivation One basic step in many bioinformatics analyses is the multiple sequence alignment. One of the state-of-the-art tools to perform multiple sequence alignment is PASTA (Practical Alignments using SATé and TrAnsitivity). PASTA supports multithreading but it is limited to process datasets on shared memory systems. In this work we introduce PASTASpark, a tool that uses the Big Data engine ...
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ژورنال
عنوان ژورنال: Science
سال: 2017
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.356.6338.646